Hormonal
Therapeutic doses of glucocorticoids (methylprednisolone) significantly increase 24-hour energy expenditure and spontaneous food intake in healthy young men, primarily by suppressing sympathetic nervous system activity and stimulating appetite.
If you are taking therapeutic doses of glucocorticoids like methylprednisolone, expect a significant increase in hunger and energy expenditure. The drug suppresses your sympathetic nervous system, which reduces energy burning and increases appetite. To manage weight, you must actively monitor and control food intake, as your body's natural regulation will shift towards consuming more calories.
Our data suggest that glucocorticoids induce obesity mostly by increasing energy intake, an effect which may be related to the ability of glucocorticoids to directly or indirectly affect the central nervous system regulation of appetite.
Why this rating
Double-blind, placebo-controlled, randomized crossover design in healthy subjects, though limited to short-term (4 days) and young males.
Source
Effects of glucocorticoids on energy metabolism and food intake in humans
P. Antonio Tataranni et al. · American Journal of Physiology-Endocrinology and Metabolism · 1996
DOI 10.1152/ajpendo.1996.271.2.e317
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →