Hormonal
Concomitant administration of recombinant human growth hormone (rhGH) prevents the protein catabolic effects of pharmacologic doses of the glucocorticoid prednisone in healthy adults.
If you are taking high-dose prednisone for a medical condition, you may experience muscle loss. This research suggests that adding human growth hormone (rhGH) can stop this muscle breakdown. However, this study was done on healthy young adults, not patients with chronic diseases, so do not attempt this without strict medical supervision.
When hGH was added to prednisone therapy, the glucocorticoid-induced protein catabolism was prevented.
Why this rating
Randomized, blinded, controlled trial with isotope dilution and nitrogen balance techniques, but small sample size (n=8 per group) and short duration (7 days).
Source
Human growth hormone prevents the protein catabolic side effects of prednisone in humans.
Fritz Horber et al. · Journal of Clinical Investigation · 1990
DOI 10.1172/jci114694
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