Research
Hormonal
Acute massive overfeeding (120 Cal/kg over 12 hours) causes a moderate (~40%) rise in serum leptin that persists into the next morning, independent of insulin levels.
Eating a large amount of food in one day (120 Cal/kg) causes your leptin levels to rise by about 40% and stay elevated overnight. This happens even if your insulin levels don't change in the same way, suggesting leptin responds directly to the energy intake.
GoodSupportsHIGH confidence
An acute, approximately 40% rise in serum leptin occurred between the fifth and tenth hours of the experiment and persisted until the morning of the following day (P < 0.01)... No correlation between insulin and leptin responses was found.
Why this rating
Controlled clinical trial, clear statistical significance, small sample size.
Source
Response of leptin to short-term and prolonged overfeeding in humans.
Jerzy W. Kolaczynski et al. · The Journal of Clinical Endocrinology & Metabolism · 1996
DOI 10.1210/jcem.81.11.8923877
clinical_trial · n=14Cited 409×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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