Hormonal
Obesity is a complex, heritable disorder resulting from the interplay of genetic susceptibility, epigenetics, metagenomics, and environmental factors, rather than solely lifestyle choices.
Recognize that obesity is a biological condition influenced by your genetics and environment, not just a failure of willpower. This understanding can reduce stigma and guide you toward evidence-based treatments, such as medications or surgeries, which may be necessary for those with specific genetic predispositions.
Being a complex and heritable disorder, obesity results from the interplay between genetic susceptibility, epigenetics, metagenomics and the environment.
Why this rating
This is a comprehensive review of high-quality genetic, epigenetic, and metagenomic studies including GWAS and monogenic syndrome analyses.
Source
Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity
Marie Pigeyre et al. · Clinical Science · 2016
DOI 10.1042/cs20160136
More from this paper
- Mutations in the leptin-melanocortin pathway genes (LEP, LEPR, POMC, PCSK1, MC4R) cause severe, early-onset obesity through hyperphagia and altered energy expenditure.Strong
- Polygenic obesity is influenced by hundreds of genetic variants affecting various biological pathways, including the central nervous system, adipocyte differentiation, and gut microbiota.Good
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →