Hormonal
Roux-en-Y gastric bypass (RYGBP) surgery significantly increases postprandial secretion of active GLP-1 and total PYY in morbidly obese subjects, which is associated with decreased hunger and increased satiety.
For patients undergoing Roux-en-Y gastric bypass, the surgery triggers a significant increase in satiety hormones (GLP-1 and PYY) after eating, which directly reduces hunger and increases feelings of fullness. This hormonal shift is a key driver of weight loss, distinct from simple stomach size reduction.
Our data show that RYGBP is associated with an improvement in the active GLP-1 and total PYY response to a liquid-meal intake. Moreover, we provide circumstantial evidence for a potential role of these gastrointestinal hormones on the decreased appetite after RYGBP.
Why this rating
Small sample size (n=9) and lack of a direct surgical control group (only BMI-matched non-surgical controls), though prospective design is strong.
Source
Glucagon-Like Peptide-1, Peptide YY, Hunger, and Satiety after Gastric Bypass Surgery in Morbidly Obese Subjects
Rosa Morı́nigo et al. · The Journal of Clinical Endocrinology & Metabolism · 2006
DOI 10.1210/jc.2005-0904
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