Hormonal
Daily administration of GTx-024 (enobosarm) at 3 mg significantly reduces insulin resistance and fasting glucose levels in healthy elderly men and postmenopausal women.
For healthy older adults, a daily 3mg dose of GTx-024 (enobosarm) taken for 12 weeks significantly reduces insulin resistance and fasting glucose levels. This metabolic benefit is comparable to standard diabetes medications like metformin, suggesting potential utility for metabolic health in aging populations.
GTx-024 3 mg significantly (P=0.006) decreased blood glucose an average of 6.9±2.5 (milligrams per deciliter)... insulin resistance (calculated based on the HOMA-IR [29]) was reduced in the GTx-024 1-mg and 3-mg treatment groups (placebo=2.6%±8.6, 1 mg=−9.3%±5.5, 3 mg=−27.5%±7.6: P=0.013 3 mg vs. placebo).
Why this rating
Phase II, randomized, double-blind, placebo-controlled clinical trial with clear statistical significance.
Source
The selective androgen receptor modulator GTx‐024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double‐blind, placebo‐controlled phase II trial
James T. Dalton et al. · Journal of Cachexia Sarcopenia and Muscle · 2011
DOI 10.1007/s13539-011-0034-6
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