Research
Hormonal
Blockade of central melanocortin receptors decreases glucose utilization in skeletal muscle and brown adipose tissue while increasing glucose uptake in white adipose tissue.
Your brain directs glucose to different tissues based on hormonal signals. When these signals are disrupted, your muscles may become less efficient at using glucose, while your fat cells become more efficient at taking it up for storage.
GoodSupportsHIGH confidence
decreased CNS-Mcr signaling promoted increased insulin sensitivity and glucose uptake in WAT while decreasing glucose utilization in muscle and brown adipose tissue.
Why this rating
Supported by euglycemic-hyperinsulinemic clamps and tissue-specific measurements.
Source
The central melanocortin system directly controls peripheral lipid metabolism
Rubén Nogueiras et al. · Journal of Clinical Investigation · 2007
DOI 10.1172/jci31743
mechanism_onlyCited 389×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Pharmacological blockade of central melanocortin receptors (CNS-Mcr) directly promotes lipid uptake, triglyceride synthesis, and fat accumulation in white adipose tissue (WAT) independent of food intake.Good
- Activation of central melanocortin receptors increases sympathetic nerve activity to white adipose tissue, leading to lipid mobilization and reduced fat storage.Good
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