Research
Hormonal
High-dose purified eicosapentaenoic acid (EPA) reduces major adverse cardiovascular events by 25% in high-risk patients with elevated triglycerides, an effect not observed with EPA/DHA combinations.
If you have high triglycerides and heart disease risk, ask your doctor about prescription EPA (icosapent ethyl). It has been proven to reduce heart attacks and strokes in people already taking statins, whereas standard fish oil supplements containing DHA have not shown the same benefit.
StrongSupportsVERY_HIGH confidence
The REDUCE-IT (Reduction of Cardiovascular Events with Icosapent Ethyl–Intervention Trial) with an EPA-only formulation reduced a composite of cardiovascular events by 25% in patients with established cardiovascular disease or diabetes mellitus and other cardiovascular risk factors.
Why this rating
Large randomized controlled trial (REDUCE-IT) with highly significant p-values.
Source
Emerging Mechanisms of Cardiovascular Protection for the Omega-3 Fatty Acid Eicosapentaenoic Acid
R. Preston Mason et al. · Arteriosclerosis Thrombosis and Vascular Biology · 2020
DOI 10.1161/atvbaha.119.313286
narrative_reviewCited 389×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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