Research
Hormonal
Central insulin signaling regulates hepatic glucose production via the vagus nerve and hepatic IL-6/STAT3 pathway, independent of peripheral insulin levels.
Insulin doesn't just work on your muscles; it also works on your brain to tell your liver to stop making sugar. If your brain is resistant to insulin, your liver may overproduce glucose, contributing to high blood sugar. Strategies that improve overall metabolic health may help restore this central signaling.
GoodSupportsHIGH confidence
They also demonstrated that infusion of insulin into the cerebroventricle suppressed HGP, irrespective of circulating insulin levels.
Why this rating
Based on animal studies showing central insulin effects on hepatic glucose production.
Source
Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism
Eun Roh et al. · Experimental & Molecular Medicine · 2016
DOI 10.1038/emm.2016.4
narrative_reviewCited 385×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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