Research
Hormonal
Knockdown of Abhd5 reduces both basal and stimulated lipolysis, indicating that Abhd5 is essential for triglyceride breakdown independent of Hormone-Sensitive Lipase (HSL).
This research shows that Abhd5 is crucial for fat burning, even when other enzymes (HSL) are blocked. This suggests that fat loss is a multi-enzyme process, and targeting only one pathway may not be sufficient for maximum fat mobilization.
GoodSupportsHIGH confidence
Knockdown of Abhd5 reduced both basal and stimulated lipolysis (p < 0.007), with the greatest absolute reduction occurring under stimulated conditions.
Why this rating
Strong evidence from siRNA knockdown experiments showing significant reduction in fatty acid efflux.
Source
Perilipin Controls Lipolysis by Regulating the Interactions of AB-hydrolase Containing 5 (Abhd5) and Adipose Triglyceride Lipase (Atgl)
James G. Granneman et al. · Journal of Biological Chemistry · 2009
DOI 10.1074/jbc.m109.068478
mechanism_onlyCited 382×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Perilipin (Plin) suppresses basal lipolysis by sequestering the co-activator Abhd5, preventing it from interacting with and activating Adipose Triglyceride Lipase (Atgl).Good
- Phosphorylation of Perilipin at specific sites (Ser-492 and Ser-517) by PKA is required to release Abhd5, allowing it to interact with and activate Atgl, thereby stimulating lipolysis.Good
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