Hormonal
The FABP2 Thr54 genetic polymorphism increases intestinal fatty acid binding affinity, leading to higher fat oxidation rates and subsequent insulin resistance.
If you carry the FABP2 Thr54 gene variant, your body is genetically predisposed to process dietary fats in a way that promotes insulin resistance. This risk is significantly amplified by a diet high in saturated fats. Managing this involves prioritizing a diet lower in saturated fats to mitigate the increased fat oxidation and insulin resistance associated with this specific genetic profile.
We conclude that the threonine-containing protein may increase absorption and/or processing of dietary fatty acids by the intestine and thereby increase fat oxidation, which has been shown to reduce insulin action.
Why this rating
Strong in vivo human data combined with in vitro mechanistic validation, though limited to a specific ethnic group (Pima Indians).
Source
An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance.
Leslie J. Baier et al. · Journal of Clinical Investigation · 1995
DOI 10.1172/jci117778
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