Research
Hormonal
Chronic metabolic acidosis induced by ammonium chloride administration decreases albumin synthesis and induces negative nitrogen balance in humans.
Sustained metabolic acidosis, even without kidney disease, can significantly slow down your body's production of albumin and lead to muscle loss. This suggests that managing acid-base balance is crucial for muscle preservation, potentially through dietary strategies that mitigate acid load.
GoodSupportsHIGH confidence
In conclusion, chronic metabolic acidosis causes negative nitrogen balance and decreases albumin synthesis in humans.
Why this rating
Controlled human trial with precise isotopic tracing, though small sample size (n=8).
Source
Chronic metabolic acidosis decreases albumin synthesis and induces negative nitrogen balance in humans.
Peter E. Ballmer et al. · Journal of Clinical Investigation · 1995
DOI 10.1172/jci117668
crossover · n=8Cited 374×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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