Hormonal
Administration of recombinant human TSH (rTSH) significantly increases FDG PET detectability and lesion-to-background ratios in patients with well-differentiated thyroid carcinoma and negative radioiodine scans compared to TSH-suppressive therapy.
For patients with well-differentiated thyroid cancer who have detectable tumor markers but negative standard scans, using recombinant TSH (rTSH) before an FDG PET scan significantly improves the ability to find hidden disease compared to standard scans done while on thyroid hormone suppression. This method avoids the need to stop thyroid medication, which causes hypothyroidism.
rTSH stimulation improves the detectability of occult thyroid metastases with FDG PET, compared with scans performed on TSH suppression.
Why this rating
Small sample size (n=7) limits statistical power, though the within-subject design controls for individual variability.
Source
The Prospective Association of Serum Insulin-Like Growth Factor I (IGF-I) and IGF-Binding Protein-1 Levels with All Cause and Cardiovascular Disease Mortality in Older Adults: The Rancho Bernardo Study
Gail A. Laughlin et al. · The Journal of Clinical Endocrinology & Metabolism · 2004
DOI 10.1210/jc.2003-030967
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