Research
Hormonal
Dysregulation of specific microRNAs (e.g., miR-375, miR-7, miR-200 family, miR-335) in pancreatic beta-cells contributes to impaired insulin secretion and beta-cell failure in Type 2 Diabetes.
This is a mechanistic explanation of why beta-cells fail in Type 2 Diabetes, involving specific microRNAs. It does not currently translate to a direct patient intervention but informs drug development.
GoodSupportsHIGH confidence
Thus, multiple miRNAs participate in and control insulin exocytosis, are dysregulated in type 2 diabetic islets and constitute natural nodes in cellular interaction networks regulating insulin exocytosis (Eliasson 2014).
Why this rating
Review of multiple genetic and functional studies in human and animal models.
Source
Micro<scp>RNA</scp>s in metabolism
Sara G. Vienberg et al. · Acta Physiologica · 2016
DOI 10.1111/apha.12681
narrative_reviewCited 371×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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