Research
Hormonal
Testosterone deficiency decreases lipid oxidation rates and resting energy expenditure, leading to increased adiposity, independent of changes in Growth Hormone (GH) production.
Low testosterone slows down your metabolism's fat-burning engine. Even if your Growth Hormone levels are normal, low testosterone will cause you to store more fat because your body oxidizes less lipid. Restoring testosterone helps restore normal fat oxidation rates.
GoodSupportsHIGH confidence
Rates of lipid oxidation decreased (−31%; P = 0.05) after treatment, with parallel changes in resting energy expenditure (−9%; P = 0.05).
Why this rating
Rigorous indirect calorimetry and DEXA measurements.
Source
Testosterone Deficiency in Young Men: Marked Alterations in Whole Body Protein Kinetics, Strength, and Adiposity<sup>1</sup>
Nelly Mauras et al. · The Journal of Clinical Endocrinology & Metabolism · 1998
DOI 10.1210/jcem.83.6.4892
crossover · n=6Cited 370×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Severe testosterone deficiency in young men causes marked decreases in whole-body protein synthesis and fat-free mass, alongside increased adiposity and decreased muscle strength, independent of changes in systemic GH or IGF-I production.Good
- Testosterone deficiency reduces whole-body protein synthesis and proteolysis rates, leading to a net decrease in protein anabolism, independent of plasma amino acid concentrations.Good
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