Hormonal
Chronic overnutrition (high glucose and lipids) induces oxidative stress and unresolved inflammation, which directly impair insulin receptor signaling and cause pancreatic beta-cell dysfunction, leading to type 2 diabetes.
To prevent or manage type 2 diabetes, focus on reducing chronic overnutrition. High intake of glucose and lipids drives oxidative stress and inflammation, which block insulin signaling and kill beta-cells. Managing body weight and diet to lower these nutrient levels can reduce inflammation and improve insulin sensitivity.
Oxidative stress and inflammation are key physiological and pathological events linking obesity, insulin resistance, and the progression of type 2 DM (T2DM).
Why this rating
Based on a comprehensive review of molecular events and multiple cited studies, though it is a review rather than a single clinical trial.
Source
Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and<i>β</i>-Cell Dysfunction
Kevin N. Keane et al. · Oxidative Medicine and Cellular Longevity · 2015
DOI 10.1155/2015/181643
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