Research
Macro partitioning
A short-term (3-day) high-fat, low-carbohydrate diet increases intramyocellular lipid (IMCL) content in the tibialis anterior muscle and decreases insulin sensitivity in healthy humans.
Eating a high-fat, low-carb diet for just three days can increase the amount of fat stored inside your leg muscles and reduce your body's sensitivity to insulin. This effect was seen even without matching calories to a low-fat diet, suggesting the type of fat and carbohydrate matters.
GoodSupportsHIGH confidence
After the high-fat diet, IMCL levels increased significantly in TA muscle (to 148.0 ± 16.9% of baseline; P < 0.005)... Insulin sensitivity decreased to 83.3 ± 5.6% of baseline (P < 0.033).
Why this rating
Controlled crossover diet study with rigorous metabolic measurements.
Source
Effects of Intravenous and Dietary Lipid Challenge on Intramyocellular Lipid Content and the Relation With Insulin Sensitivity in Humans
Oliver Bachmann et al. · Diabetes · 2001
DOI 10.2337/diabetes.50.11.2579
rct · n=12Cited 370×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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