Macro partitioning
Carriers of the BMI-increasing FTO rs9939609 minor allele exhibit a specific genetic predisposition to consume higher dietary protein, independent of total energy intake or BMI.
If you carry the FTO risk variant for obesity, you may have a biological tendency to prefer protein-rich foods. Instead of viewing this as a flaw, use it: structure your meals to be higher in protein. This aligns with your genetic appetite signals, potentially making it easier to manage satiety and body weight without strictly counting total calories.
The BMI-increasing allele of the FTO variant showed a significant association with higher dietary protein intake (effect per allele = 0.08 [0.06, 0.10] %, P = 2.4 × 10^-16)... The associations with protein... were attenuated but remained significant after adjustment for BMI.
Why this rating
Meta-analysis of 177,330 individuals provides extremely high statistical power and low heterogeneity for this specific association.
Source
FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals
Qibin Qi et al. · Human Molecular Genetics · 2014
DOI 10.1093/hmg/ddu411
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