Hormonal
Testosterone replacement therapy reverses glucocorticoid-induced bone loss and muscle wasting in hypogonadal men, increasing lumbar spine bone density by 5.0% and restoring lean body mass.
If you are a man on long-term steroids (like for asthma) and have low testosterone, testosterone replacement therapy can significantly strengthen your bones and restore muscle mass. The treatment involves monthly injections and is generally well-tolerated, though it may lower 'good' cholesterol (HDL). The benefits for bone health and muscle mass often outweigh the risks for men with serious conditions requiring steroids.
Testosterone treatment reverses the deleterious effects of glucocorticoid drugs on skeletal and soft tissues in men. Bone density in the lumbar spine increased 5.0%... There was a gain in body fat mass... and a loss of lean body mass... during the control period, with both changes being reversed by testosterone treatment.
Why this rating
Randomized controlled crossover design with a small sample size (n=15) and short duration (12 months per period).
Source
Testosterone Therapy in Glucocorticoid-Treated Men
Ian Reid · Archives of Internal Medicine · 1996
DOI 10.1001/archinte.1996.00440100065008
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