Hormonal
Low testosterone in men with type 2 diabetes and obesity is associated with increased cardiovascular disease risk and erectile dysfunction, mediated by visceral adiposity and proinflammatory cytokines.
If you have type 2 diabetes and are obese, getting your testosterone checked is important. Low levels are linked to higher heart disease risk and sexual dysfunction. Treatment with testosterone replacement may help, but it must be done carefully with monitoring for side effects, especially in older men.
Visceral adiposity present in men with low testosterone, the metabolic syndrome, and/or type 2 diabetes acts through proinflammatory factors. These inflammatory markers contribute to vascular endothelial dysfunction with adverse sequelae such as increased cardiovascular disease (CVD) risk and erectile dysfunction.
Why this rating
Based on multiple epidemiological studies, longitudinal data, and meta-analyses cited in the review.
Source
Low Testosterone Associated With Obesity and the Metabolic Syndrome Contributes to Sexual Dysfunction and Cardiovascular Disease Risk in Men With Type 2 Diabetes
Christina Wang et al. · Diabetes Care · 2011
DOI 10.2337/dc10-2339
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