Macro partitioning

Replacing saturated fat with linoleic acid-rich vegetable oils lowers serum cholesterol but does not reduce mortality from coronary heart disease or all-cause mortality, and may be associated with higher risk of death in those with greater cholesterol reductions.

Current dietary guidelines recommending the replacement of saturated fats with linoleic acid-rich vegetable oils (like corn or soybean oil) to lower cholesterol do not appear to reduce the risk of death from heart disease or all causes. In fact, this specific large-scale trial suggests that achieving lower cholesterol through this method might be associated with a higher risk of death. Individuals should be aware that lowering cholesterol via this specific dietary swap may not confer the expected survival benefit.