Hormonal
Regular exercise training acts as an effective antioxidant therapy by upregulating vascular eNOS and antioxidant enzymes (SOD1, SOD3) while downregulating pro-oxidant enzymes (NAD(P)H oxidase), thereby improving endothelial function and reducing cardiovascular risk.
Engage in regular, moderate exercise (e.g., brisk walking or cycling) consistently. This triggers your body's natural antioxidant defenses, improving blood vessel health and reducing cardiovascular risk more effectively than many drugs, without the side effects.
Based on these observations, it appears reasonable to assume that exercise training can be viewed as an effective antioxidant and antiatherogenic therapy.
Why this rating
The paper is a review citing multiple clinical trials and animal studies, though it acknowledges variability in human responses.
Source
Molecular mechanisms of vascular adaptations to exercise. Physical activity as an effective antioxidant therapy?
Georg Kojda et al. · Cardiovascular Research · 2005
DOI 10.1016/j.cardiores.2005.04.032
More from this paper
- The vascular benefits of exercise, specifically eNOS upregulation, are transient and depend on baseline activity levels; sedentary individuals see significant gains, while active individuals see minimal changes.Good
- Exercise-induced vascular remodeling (angiogenesis and arteriogenesis) improves organ blood flow and can compensate for occluded arteries, particularly in patients with cardiovascular disease.Good
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