Hormonal
Fasting-induced PGC-1α activation of the nuclear receptor FXR reduces plasma triglyceride levels in wild-type mice, a mechanism absent in FXR-null mice.
Fasting is a powerful tool for lowering triglycerides, but its effectiveness relies on a functional FXR pathway. If you have genetic variations affecting this receptor, fasting might not lower your triglycerides and could potentially raise them. This mechanism highlights why individual responses to fasting vary.
Consistent with these in vitro studies, we demonstrate that fasting induces hepatic expression of PGC-1α and FXR and results in decreased plasma triglyceride levels in wild-type but not in FXR-null mice.
Why this rating
Strong in vivo evidence using knockout models and primary hepatocytes, though translated to humans.
Source
Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) regulates triglyceride metabolism by activation of the nuclear receptor FXR
Yanqiao Zhang et al. · Genes & Development · 2004
DOI 10.1101/gad.1138104
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