Research
Hormonal
Long-term supplemental intakes of combined EPA and DHA up to 5 g/day do not increase the risk of spontaneous bleeding episodes or bleeding complications, even in subjects at high risk of bleeding.
If you are taking high-dose fish oil (up to 5g/day combined EPA/DHA), you do not need to worry about an increased risk of bleeding, even if you are on blood thinners like aspirin or warfarin. This safety profile holds for long-term use in adults.
GoodRefutesHIGH confidence
Long-term supplemental intakes of EPA and DHA combined up to about 5 g/day do not increase the risk of spontaneous bleeding episodes or bleeding complications even in subjects at high risk of bleeding (e.g. taking acetylsalicylic acid or anti-coagulants).
Why this rating
Based on a large number of human intervention studies reviewed by an authoritative body (EFSA).
Source
Scientific Opinion on the Tolerable Upper Intake Level of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA)
EFSA Panel on Dietetic Products et al. · EFSA Journal · 2012
DOI 10.2903/j.efsa.2012.2815
Meta-analysisCited 358×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Supplemental intakes of EPA and DHA combined up to 5 g/day, and EPA alone up to 1.8 g/day, do not raise safety concerns for adults.Strong
- Supplemental intakes of EPA and DHA combined at doses of 2-6 g/day, and DHA at 2-4 g/day, increase LDL-cholesterol by about 3%, but this increase is accompanied by a decrease in triglycerides and does not adversely affect cardiovascular disease risk.Good
- Supplemental intakes of EPA and DHA combined up to 5 g/day do not significantly affect glucose homeostasis in healthy or diabetic subjects.Good
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