Research
Hormonal
SIRT1 deficiency or inhibition leads to increased hepatic oxidative stress and inflammation by failing to deacetylate FOXO transcription factors and NF-kappaB, promoting the progression from steatosis to steatohepatitis.
Fatty liver isn't just about fat storage; it triggers inflammation and oxidative stress that damage the liver further. SIRT1 helps mitigate this by regulating antioxidant and anti-inflammatory pathways. Maintaining metabolic health supports these protective mechanisms.
GoodSupportsHIGH confidence
SIRT1 supports a beneficial effect on hepatic oxidative stress as well as associated fatty liver diseases, and this protective action is possibly through stimulation of FOXOs and PGC-1alpha... SIRT1 interacts with RelA/p65... and inhibits its transcriptional activity by deacetylating RelA/p65 at lysine 310.
Why this rating
Supported by genetic models showing increased ROS and cytokines in SIRT1-deficient mice.
Source
Emerging roles of SIRT1 in fatty liver diseases
Ren‐Bo Ding et al. · International Journal of Biological Sciences · 2017
DOI 10.7150/ijbs.19370
narrative_reviewCited 358×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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