Hormonal
Low insulin-stimulated glucose disposal (M) and low acute insulin secretory response (AIR) are independent and additive predictors of the progression from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) and from IGT to type 2 diabetes.
If you have normal or pre-diabetic blood sugar, your body's ability to use insulin (sensitivity) and its ability to release insulin quickly (secretion) are the two main levers determining if you develop diabetes. Both matter equally at every stage. Monitoring these metrics can help identify high-risk individuals for early intervention.
low M and low AIR were independent predictors of both the progression from NGT to IGT... and from IGT to diabetes
Why this rating
Prospective longitudinal study with direct measurement (clamps/IVGTT) and long follow-up (up to 13 years).
Source
Insulin Resistance and Insulin Secretory Dysfunction Are Independent Predictors of Worsening of Glucose Tolerance During Each Stage of Type 2 Diabetes Development
Christian Weyer et al. · Diabetes Care · 2001
DOI 10.2337/diacare.24.1.89
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