Hormonal
Curcumin extends the lifespan of model organisms (C. elegans, D. melanogaster, yeast, and mice) by modulating longevity signaling pathways (IIS, mTOR, PKA, FOXO) and enhancing antioxidant defenses (Nrf2/HO-1, SOD).
Curcumin, the active compound in turmeric, appears to activate cellular stress-response pathways (like Nrf2 and FOXO) that are linked to longevity in animal studies. While human lifespan extension isn't proven, its anti-inflammatory and antioxidant properties may support healthy aging. Consider incorporating turmeric/curcumin as part of a diet rich in polyphenols, potentially with black pepper or lipids to enhance absorption, though it is not a magic bullet for longevity.
Recently, investigations on curcumin with regard to aging and age-associated disease in model organisms has described that curcumin and its metabolites, prolong the mean lifespan of some aging model organisms such as C. elegans, D. melanogaster, yeast, and mouse.
Why this rating
Evidence is strong in invertebrate and murine models but lacks robust human clinical trials for lifespan extension.
Source
The role of curcumin in aging and senescence: Molecular mechanisms
Aliabbas Zia et al. · Biomedicine & Pharmacotherapy · 2020
DOI 10.1016/j.biopha.2020.111119
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