Hormonal
Continuous positive airway pressure (CPAP) significantly reduces 24-hour mean arterial blood pressure in patients with moderate-to-severe obstructive sleep apnea, even when cardiovascular risk factors are well-managed with pharmacotherapy.
If you have moderate-to-severe sleep apnea and high blood pressure or heart disease, using CPAP at night can lower your blood pressure, even if you are already taking blood pressure medications. While the drop in blood pressure is modest (about 2-3 mmHg), it is a proven benefit. Supplemental oxygen alone does not provide this blood pressure benefit, so CPAP remains the superior treatment for cardiovascular risk reduction in this population.
In patients with cardiovascular disease or multiple cardiovascular risk factors, the treatment of obstructive sleep apnea with CPAP, but not nocturnal supplemental oxygen, resulted in a significant reduction in blood pressure.
Why this rating
Randomized, controlled trial with 318 participants, published in NEJM.
Source
CPAP versus Oxygen in Obstructive Sleep Apnea
Daniel J. Gottlieb et al. · New England Journal of Medicine · 2014
DOI 10.1056/nejmoa1306766
More from this paper
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →