Hormonal
Targeted delivery of propionate to the proximal colon improves glucose metabolism and reduces energy intake without requiring high fiber intake or a responsive gut microbiota.
If your gut bacteria don't produce enough short-chain fatty acids (SCFAs) from fiber, targeted delivery systems (like inulin-propionate esters) can release propionate directly in the colon to improve insulin sensitivity and reduce energy intake.
targeted delivery of propionate was demonstrated to acutely reduce energy intake and ameliorate long-term weight gain in overweight adults... significantly improved acute insulin secretion and beta cell function
Why this rating
Based on specific trials using an inulin-propionate ester; promising but described as a 'future possibility' requiring more research.
Source
The gut microbiome as a target for prevention and treatment of hyperglycaemia in type 2 diabetes: from current human evidence to future possibilities
Louise Brunkwall et al. · Diabetologia · 2017
DOI 10.1007/s00125-017-4278-3
More from this paper
- Metformin's primary glucose-lowering mechanism involves altering gut microbiota composition to increase butyrate and propionate production and enhance GLP-1 secretion, rather than solely acting via hepatic pathways.Good
- Faecal Microbiota Transplantation (FMT) from lean donors shows promise for improving insulin sensitivity in metabolic syndrome, but current human evidence is limited, small, and unreplicated.Limited
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