Hormonal
Intramuscular androgen receptor content, rather than systemic or intramuscular hormone levels, determines the magnitude of resistance training-induced skeletal muscle hypertrophy in healthy, young men.
If you are a healthy, young man who already lifts weights regularly, your muscle growth potential is likely determined by your genetic muscle receptor density, not your blood testosterone levels. You cannot change your receptor density with supplements or TRT if your levels are already normal. Focus on consistent, progressive resistance training rather than trying to manipulate hormones.
These results indicate that intramuscular androgen receptor content, but neither circulating nor intramuscular hormones (or the enzymes regulating their intramuscular production), influence skeletal muscle hypertrophy following RET in previously trained young men.
Why this rating
Randomized controlled trial with a relatively large sample size (n=49) and rigorous statistical analysis (PCA, stepwise regression), though the subgroup analysis for receptor content was limited (n=20).
Source
Muscle Androgen Receptor Content but Not Systemic Hormones Is Associated With Resistance Training-Induced Skeletal Muscle Hypertrophy in Healthy, Young Men
Robert W. Morton et al. · Frontiers in Physiology · 2018
DOI 10.3389/fphys.2018.01373
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