Research
Hormonal
Dehydroepiandrosterone (DHEA) is not recommended for general use in women due to inadequate indications and lack of evidence for efficacy and long-term safety.
Do not use DHEA supplements for general health, bone density, or cognitive enhancement. There is insufficient evidence to support its efficacy or long-term safety in women.
WeakRefutesHIGH confidence
We recommend against the generalized use of DHEA for women because the indications are inadequate, and evidence of efficacy and long-term safety are lacking.
Why this rating
Strong recommendation (1) based on limited data concerning effectiveness and safety.
Source
Androgen Therapy in Women: A Reappraisal: An Endocrine Society Clinical Practice Guideline
Margaret E. Wierman et al. · The Journal of Clinical Endocrinology & Metabolism · 2014
DOI 10.1210/jc.2014-2260
clinical_guidelineCited 355×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Testosterone therapy is conditionally recommended for postmenopausal women with properly diagnosed hypoactive sexual desire disorder (HSDD) to achieve midnormal premenopausal levels, with monitoring for androgen excess.Limited
- Testosterone therapy is not recommended for healthy women or those with conditions other than hypoactive sexual desire disorder (HSDD) due to lack of defined syndrome, unclear correlation between levels and symptoms, and insufficient long-term safety data.Weak
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