Research
Hormonal
TLR4 signaling is a key pathway for the progression of NAFLD, driven by circulating LPS from gut microbiota.
Focus on reducing gut permeability through diet (e.g., fiber, probiotics) to lower LPS levels, which may reduce liver inflammation via the TLR4 pathway.
GoodSupportsHIGH confidence
Thus, LPS is closely associated with the development of NAFLD, and TLR4 signaling is a key pathway for the progression of NAFLD in humans as well as rodents.
Why this rating
Strong evidence from multiple rodent models and human studies showing elevated LPS and TLR4 expression.
Source
Role of gut microbiota and Toll-like receptors in nonalcoholic fatty liver disease
Kouichi Miura · World Journal of Gastroenterology · 2014
DOI 10.3748/wjg.v20.i23.7381
narrative_reviewCited 354×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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