Research
Macro partitioning
ATF3 induction by synthetic agents like ST32da promotes adipocyte browning and inhibits lipogenesis, potentially offering a mechanism to combat obesity.
Research indicates that inducing ATF3 expression can help convert white fat to beige/brown fat, which burns energy. A synthetic inducer called ST32da was shown to do this in mice by blocking specific fat-making pathways. This is not yet a available treatment for humans.
ModerateSupportsMEDIUM confidence
We further found that ST32da, a synthetic ATF3 inducer selected from an ATF3-specific promoter screening platform, enhances ATF3 expression to inhibit adipogenesis/lipogenesis and promote adipocyte browning by inhibiting the carbohydrate-responsive element-binding protein–stearoyl-CoA desaturase-1 axis (ChREBP-SCD-1).
Why this rating
Based on in vitro studies and transgenic mouse models; no human data.
Source
Master Regulator Activating Transcription Factor 3 (ATF3) in Metabolic Homeostasis and Cancer
Hui‐Chen Ku et al. · Frontiers in Endocrinology · 2020
DOI 10.3389/fendo.2020.00556
narrative_reviewCited 349×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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