Hormonal
Patients taking SGLT2 inhibitors should omit these medications the day before and the day of surgery to prevent euglycemic diabetic ketoacidosis (DKA).
If you take an SGLT2 inhibitor (like Jardiance, Farxiga, or Invokana) for your upcoming elective surgery, stop taking it the day before your surgery and do not take it on the day of surgery. This is critical to prevent a rare but serious condition called euglycemic DKA. Your medical team will monitor your blood sugar closely during your stay and manage it with insulin if necessary, which is the safest approach.
Patients taking sodium-glucose cotransporter-2 inhibitors should omit them the day before and the day of a procedure.
Why this rating
Based on a multidisciplinary consensus statement using a modified Delphi process, acknowledging 'contradictory recommendations' and 'significant confounding' in existing data.
Source
Elective peri‐operative management of adults taking glucagon‐like peptide‐1 receptor agonists, glucose‐dependent insulinotropic peptide agonists and sodium‐glucose cotransporter‐2 inhibitors: a multidisciplinary consensus statement
Kariem El‐Boghdadly et al. · Anaesthesia · 2025
DOI 10.1111/anae.16541
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