Research
Hormonal
Oral testosterone supplementation in elderly men with low-normal gonadal status leads to a significant increase in hematocrit levels.
Older men on testosterone therapy should have their hematocrit monitored regularly. An increase is expected, and if it becomes too high (above 50%), the dose may need to be reduced to prevent potential cardiovascular risks.
GoodSupportsHIGH confidence
Hematocrit increased by 2% over 12 months in the testosterone group and did not change in the placebo group (p = .026).
Why this rating
Statistically significant result (p=.026) in a randomized controlled trial.
Source
Oral Testosterone Supplementation Increases Muscle and Decreases Fat Mass in Healthy Elderly Males With Low-Normal Gonadal Status
Gary Wittert et al. · The Journals of Gerontology Series A · 2003
DOI 10.1093/gerona/58.7.m618
rct · n=76Cited 346×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Oral testosterone supplementation (80 mg twice daily) increases lean body mass and decreases fat mass in healthy elderly men (aged 60+) with low-normal gonadal status over a 12-month period.Good
- Oral testosterone supplementation in elderly men with low-normal gonadal status leads to a significant decrease in High-Density Lipoprotein (HDL) cholesterol levels.Good
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