Macro partitioning
A very-low-carbohydrate, high-saturated-fat diet leads to greater weight loss and abdominal fat reduction compared to a high-carbohydrate, low-saturated-fat diet, but results in less favorable changes in LDL cholesterol and C-reactive protein.
A very-low-carbohydrate diet may help you lose slightly more weight and abdominal fat than a high-carbohydrate diet over 8 weeks. However, this comes at the cost of less improvement in LDL cholesterol and inflammation (CRP) compared to a high-carbohydrate diet. If you have high cholesterol or inflammation, a high-carbohydrate diet might be a better choice for your cardiovascular markers, even if weight loss is slightly slower.
More weight (P < 0.05 for diet × time interaction) and more abdominal fat mass (P < 0.05 for diet × time interaction) were lost with the LC than with the HC. LDL cholesterol decreased more with the HC than with the LC (P < 0.05, time × diet), and C-reactive protein decreased more with the HC than with the LC (P < 0.05 for diet × time interaction).
Why this rating
RCT with clear statistical interactions reported for weight, LDL, and CRP.
Source
Obesity and Endothelial Function
Masato Kajikawa et al. · Biomedicines · 2022
DOI 10.3390/biomedicines10071745
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