Hormonal
Knocking down Ketohexokinase (KHK), the first enzyme in fructose metabolism, improves hepatic steatosis and glucose tolerance in fructose-supplemented mice.
This paper identifies Ketohexokinase (KHK) as a key enzyme in fructose metabolism. Inhibiting KHK in mice improved liver fat and glucose tolerance. While this suggests a potential future therapeutic target for fatty liver disease, the most immediate action for humans is to reduce fructose intake, especially with high-fat diets.
Knockdown of ketohexokinase in liver improved hepatic steatosis and glucose tolerance in fructose-supplemented mice.
Why this rating
Validated in animal models with human biomarker correlation (KHK elevation in NASH patients).
Source
Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling
Samir Softic et al. · Journal of Clinical Investigation · 2017
DOI 10.1172/jci94585
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