Macro partitioning
Knocking down hepatic Adipose Triglyceride Lipase (ATGL) causes hepatic steatosis by blocking triacylglycerol (TAG) hydrolysis and reducing fatty acid oxidation.
Your liver has a specific enzyme (ATGL) that breaks down stored fat. If this enzyme is suppressed, your liver stores more fat (steatosis) and burns less of it, even if you aren't eating excess calories. Maintaining healthy hepatic ATGL activity is crucial for preventing fatty liver and ensuring fatty acids are burned for energy rather than stored.
Adenovirus-mediated knockdown of hepatic ATGL resulted in steatosis in mice and decreased hydrolysis of TAG in primary hepatocyte cultures and in vitro assays.
Why this rating
The study uses rigorous in vivo and in vitro models (adenoviral knockdown, primary hepatocytes) with clear mechanistic pathways, though it is an animal study.
Source
Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning
Kuok Teong Ong et al. · Hepatology · 2010
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