Hormonal
Aging is associated with an attenuated rise in muscle protein synthesis rate following the ingestion of dietary protein, a phenomenon termed anabolic inflexibility.
As you age, your muscles become less sensitive to the muscle-building signal from protein. This doesn't mean protein is useless, but it means you likely need to consume more protein per meal to get the same muscle-building effect you got when you were younger. Focus on ensuring adequate protein intake at each meal rather than just total daily volume.
The present study demonstrates that an advanced age is associated with a blunted muscle protein synthetic response to protein ingestion... We conclude that the development of anabolic inflexibility contributes to the loss of muscle mass with aging.
Why this rating
Large cohort retrospective cross-sectional study using stable isotope methodologies, though not a randomized intervention trial.
Source
Aging Is Accompanied by a Blunted Muscle Protein Synthetic Response to Protein Ingestion
Benjamin T. Wall et al. · PLoS ONE · 2015
DOI 10.1371/journal.pone.0140903
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