Research
Hormonal
Perilipin 2 (PLIN2) and Perilipin 5 (PLIN5) overexpression in skeletal muscle can protect against lipotoxicity and improve insulin signaling by sequestering fatty acids into lipid droplets, thereby reducing toxic lipid intermediates like DAG and ceramides.
Endurance training and metabolic health can upregulate protective proteins like PLIN5, which help store fatty acids safely in lipid droplets. This prevents them from turning into toxic byproducts that block insulin action. Prioritize exercises that improve metabolic flexibility.
GoodSupportsHIGH confidence
Accordingly, PLIN2 overexpression reverts palmitate-induced impairments in insulin signaling [77]. ... PLIN5 overexpression in skeletal muscle is capable of protecting the cells against lipotoxicity by increasing the amount of esterified lipid chains into LDs [103]. DAG accumulation is reduced in PLIN5 overexpressing myotubes treated with palmitate...
Why this rating
Cites specific overexpression studies in cell lines and animal models.
Source
Muscle Lipid Metabolism: Role of Lipid Droplets and Perilipins
Pablo E. Morales et al. · Journal of Diabetes Research · 2017
DOI 10.1155/2017/1789395
narrative_reviewCited 335×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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