Hormonal
Once-weekly subcutaneous tirzepatide (5, 10, and 15 mg) produces significant, dose-dependent weight loss and improvements in cardiometabolic markers compared to placebo in adults with or without type 2 diabetes.
If you are an adult with obesity or overweight (with or without Type 2 Diabetes), once-weekly tirzepatide injections (5-15 mg) are a highly effective medical intervention for weight loss, averaging 8-12% body weight reduction depending on the dose. It also improves blood pressure, blood sugar, and lipids. While you may experience temporary gastrointestinal issues like nausea, these are usually mild and subside over time. This treatment is significantly more effective than older anti-obesity drugs and is generally safe, with no increased risk of serious adverse events compared to placebo.
Compared to the placebo group, tirzepatide at doses of 5, 10, and 15 mg demonstrated significant dose-dependent weight loss. The mean difference (MD) in the percentage change in body weight (BW) was −8.07%... −10.79%... and −11.83%... respectively.
Why this rating
Based on 7 RCTs with 4,795 participants; however, certainty for some outcomes (e.g., weight loss percentages) was rated 'low' or 'moderate' due to heterogeneity and study design variations.
Source
Efficacy and safety of once-weekly tirzepatide for weight management compared to placebo: An updated systematic review and meta-analysis including the latest SURMOUNT-2 trial
Wenhui Qin et al. · Endocrine · 2024
DOI 10.1007/s12020-024-03896-z
Related findings · Hormonal
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