Research
Hormonal
Elevated leptin levels in obesity promote cancer cell survival, proliferation, and migration by inducing anti-apoptotic, pro-inflammatory, and angiogenic factors.
Managing obesity helps lower leptin levels, which may reduce the stimulation of cancer cell growth and survival pathways.
ModerateSupportsHIGH confidence
In this context increased leptin levels lead to increased expression of anti-apoptotic, pro-inflammatory and angiogenic factors that promote proliferation and migration of cancer cells.
Why this rating
Review paper citing multiple studies.
Source
Obesity and cancer: the role of adipose tissue and adipo-cytokines-induced chronic inflammation
Rosa Divella et al. · Journal of Cancer · 2016
DOI 10.7150/jca.16884
narrative_reviewCited 332×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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