Hormonal
Activation of AMPK β1 in macrophages reduces lipid-induced inflammation and insulin resistance by increasing fatty acid oxidation and mitochondrial content.
While this study focuses on mice, it suggests that maintaining healthy macrophage function through a balanced diet and regular exercise may help reduce inflammation and improve insulin sensitivity. Specifically, avoiding excessive saturated fat intake and promoting fatty acid oxidation through physical activity could be beneficial.
Thus, activation of AMPK β1 and increasing fatty acid oxidation in macrophages may represent a new therapeutic approach for the treatment of insulin resistance.
Why this rating
Strong in vivo evidence using bone marrow transplantation and high-fat diet challenges in mice, though not directly translatable to human clinical trials yet.
Source
Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity
Sandra Galić et al. · Journal of Clinical Investigation · 2011
DOI 10.1172/jci58577
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