Hormonal
Oral vanadyl sulfate (100 mg/day) improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus (NIDDM) by enhancing glucose disposal and suppressing hepatic glucose production.
For individuals with type 2 diabetes, vanadyl sulfate at 100mg daily may significantly improve how their body uses insulin, leading to better blood sugar control. However, it can cause mild stomach issues, and its long-term safety is not yet established, so medical supervision is essential.
These results indicate that 3 wk of treatment with VS improves hepatic and peripheral insulin sensitivity in insulin-resistant NIDDM humans.
Why this rating
Small sample size (n=6) and short duration (3 weeks), but rigorous methodology (euglycemic hyperinsulinemic clamps).
Source
Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus.
Neil Cohen et al. · Journal of Clinical Investigation · 1995
DOI 10.1172/jci117951
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