Hormonal
High-fat, low-carbohydrate meals suppress 24-hour circulating leptin levels compared to low-fat, high-carbohydrate meals, which contributes to increased energy intake and weight gain.
If you are trying to manage weight, be aware that high-fat, low-carb meals may leave you feeling less satiated over 24 hours than high-carb meals. This is because fat doesn't trigger the insulin-leptin pathway that signals long-term energy sufficiency to your brain. Including carbohydrates can help boost leptin levels, potentially reducing hunger and preventing overeating.
Evidence suggests that anaerobic metabolism of glucose to lactate does not stimulate leptin production... suggesting a mechanism that may contribute to the effects that high-fat diets have in promoting increased energy intake, weight gain and obesity.
Why this rating
Supported by multiple human studies cited (Havel et al. 1999) showing significant differences in 24h leptin profiles.
Source
Role of adipose tissue in body-weight regulation: mechanisms regulating leptin production and energy balance
Peter J. Havel · Proceedings of The Nutrition Society · 2000
DOI 10.1017/s0029665100000410
More from this paper
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →