Hormonal
Oleoylethanolamide (OEA) stimulates lipolysis and fatty acid oxidation in adipose tissue and skeletal muscle by activating the nuclear receptor PPAR-α, leading to reduced body weight gain and tissue triacylglycerol content in diet-induced obese rodents.
OEA is an endogenous lipid that activates PPAR-α to increase fat burning (lipolysis and oxidation) and reduce body weight in obese states. While it also reduces appetite, its ability to directly stimulate fat utilization appears crucial for weight loss in obese individuals. This mechanism suggests OEA or PPAR-α agonists could be used to target fat storage directly.
The results suggest that OEA stimulates fat utilization through activation of PPAR-α and that this effect may contribute to its anti-obesity actions.
Why this rating
Strong mechanistic evidence using wild-type and PPAR-α knockout mice, plus synthetic agonist controls, though limited to rodent models.
Source
Oleoylethanolamide Stimulates Lipolysis by Activating the Nuclear Receptor Peroxisome Proliferator-activated Receptor α (PPAR-α)
Manuel Guzmán et al. · Journal of Biological Chemistry · 2004
DOI 10.1074/jbc.m404087200
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