Hormonal
Specific probiotic and synbiotic interventions improve liver function markers (ALT, AST) and reduce liver fat in patients with Non-Alcoholic Fatty Liver Disease (NAFLD) and NASH.
If you have NAFLD or NASH, specific probiotics (like L. bulgaris/S. thermophilus or synbiotics with L. plantarum) taken daily for 8-30 weeks may help improve liver enzyme levels and reduce liver fat. This is a supportive strategy alongside lifestyle changes.
some probiotics and synbiotics improved the liver and metabolic parameters in patients with NAFLD... synbiotic supplementation inhibited NF-kB and reduced TNF-alpha production
Why this rating
Based on review of RCTs, but results are mixed regarding specific inflammatory markers.
Source
Effects of Probiotics and Synbiotics on Obesity, Insulin Resistance Syndrome, Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease: A Review of Human Clinical Trials
María José Sáez‐Lara et al. · International Journal of Molecular Sciences · 2016
DOI 10.3390/ijms17060928
More from this paper
- Specific probiotic and synbiotic strains reduce body mass index (BMI), visceral fat area, and fat mass in overweight or obese adults and children.Moderate
- Specific probiotic and synbiotic interventions improve insulin sensitivity, fasting blood glucose, and lipid profiles in patients with Type 2 Diabetes (T2D) and Insulin Resistance Syndrome (IRS).Moderate
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →