Research
Hormonal
Humoral factors, including cytokines and hormones activated by waking activity and pathogens, regulate sleep, linking the immune system directly to sleep promotion.
When you are sick, sleep is your body's active immune response. Prioritize rest during illness as it helps regulate immune function and recovery.
GoodSupportsHIGH confidence
These sleep-promoting humoral factors are activated, in part, through their respective pattern recognition receptors, thereby providing a link between the immune system and sleep regulation.
Why this rating
Supported by historical and modern research on humoral factors.
Source
Functions and Mechanisms of Sleep
Mark R. Zielinski et al. · AIMS neuroscience · 2016
DOI 10.3934/neuroscience.2016.1.67
narrative_reviewCited 326×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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