Hormonal
Common variants in genes influencing pancreatic beta-cell function make a significant contribution to the inherited component of Type 2 diabetes, often with small individual effects.
Type 2 diabetes is not caused by a single 'diabetes gene' but by a combination of many common genetic variants, each with a small effect. This genetic complexity means that your risk is the sum of many small genetic contributions. Understanding this can help explain why some people with similar lifestyles have different diabetes risks.
These results confirm the genetic complexity of Type 2 diabetes and provide evidence that common variants in genes influencing pancreatic b-cell function may make a significant contribution to the inherited component of this disease.
Why this rating
Large-scale study with robust statistical power calculations.
Source
Candidate Gene Association Study in Type 2 Diabetes Indicates a Role for Genes Involved in β-Cell Function as Well as Insulin Action
Inês Barroso et al. · PLoS Biology · 2003
DOI 10.1371/journal.pbio.0000020
More from this paper
- Common genetic variants in genes primarily influencing pancreatic beta-cell function (specifically ABCC8, KCNJ11, SLC2A2, HNF4A, and INS) significantly alter the risk of developing Type 2 diabetes.Good
- Common variants in genes primarily influencing insulin action (specifically INSR, PIK3R1, and SOS1) are significantly associated with Type 2 diabetes risk.Good
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