Hormonal
Polyunsaturated fatty acids (PUFAs), particularly n-3 PUFAs like EPA and DHA, protect against ischemia/reperfusion injury and reduce cardiovascular disease risk by modulating inflammation and ion channels.
Increase your intake of n-3 polyunsaturated fatty acids (PUFAs) found in fish (EPA, DHA) and plant sources like flaxseed (ALA). These fats help reduce inflammation and protect the heart during stress events like ischemia. Be mindful of n-6 PUFA intake, as excessive amounts may promote inflammation.
Polyunsaturated fatty acids appear to provide important protection to the heart during ischemic reperfusion challenge. Conversely, trans fatty acids are thought to mediate detrimental cardiac effects.
Why this rating
Strong in vitro and animal evidence, with some human observational data, though some specific mechanisms (like ALA vs EPA/DHA) remain controversial.
Source
Trans Fatty Acids and Cardiovascular Disease
Dariush Mozaffarian et al. · Obstetrical & Gynecological Survey · 2006
DOI 10.1097/01.ogx.0000228706.09374.e7
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